Ketamine (HCl) 50mg/10ml
Ketamine (HCl) non barbiturate, sedative hypnotic used parenterally to provide anaesthesia for short diagnostic and surgical procedures. Ketamine (HCl) is arylcyclohexalamine chemically related to phencyclidine (PCP). Ketamine is a fairly short-acting anaesthetic that provides a profound, rapid, dissociative anesthesia and a short recovery time. Ketamine (HCl) is a desirable agent in patients who are hypotensive. Ketamine (HCl) can be used concomitantly with a muscle relaxants without complication because Ketamine (HCl) does not provide muscle relaxation. Ketamine efficacy is offset by the frequent occurrence of dysphoria. Ketamine received FDA approval in 1970. Although the exact mechanism of action is not known, ketamine appears to be an agonist at CNS muscarinic acetylcholine-receptors and opiate-receptors.
The severe or irreversible adverse effects of Ketamine (HCl), which give rise to further complications include Sinus tachycardia, Hallucinations, Hypotension, Hallucinations, Hypotension, Maculopapular rash, Hypertension, Sinus bradycardia, Respiratory depression, Laryngospasm.
The symptomatic adverse reactions produced by Ketamine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Anorexia, Skin rashes, Diplopia, Nightmares, Psychomimetic reaction, Nystagmus, Delirium, Apnea, Pain at injection site, Skin rashes, Pain at injection site.
Ketamine (HCl)’s dosage details are as follows:
|6.5 to 13 mg/kg||9.8 (9.75)||24 hourly||IM||For 3-4 min|
|2 mg/kg||2 (2)||24 hourly||IV||Slowly over 60 sec.|
|0.5 to 2 mg/kg||1.2 (1.25)||24 hourly||IVInfusion|
Paedriatic Dosage (20kg)
|3 to 7 mg/kg||5 (5)||As recommended.||Intra Muscular||As Required|
|0.5 to 2 mg/kg||1.2 (1.25)||As recommended.||Intravenous||As required|
Neonatal Dosage (3kg)
High Risk Groups
Drug should not be given to Cardiac / Hypertensive Patients.
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Warning / Precautions
Do not administer ketamine alone in case of surgery or diagnostic procedures of pharynx, larynx. Avoid use in patients with hypertension and history of cerebrovascular accident or increase intraocular pressure. It should be used with caution in patients with elevated CSF pressure. It should be used with caution in chronic alcoholic and acutely alcohol intoxicated patients. Do not drive, operate hazardous machinery for 24 hrs.or more after taking drug. It should be avoided in pateints prone to hallurinations & psychotic disorders.
IV Inj, IV Inf, IM Inj
Store at room temperature, Below 30°C. Do not Freeze. Protect from Sunlight.
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